Thread: Neutropenia
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Old Tue Jan 5, 2010, 07:56 AM
Birgitta-A Birgitta-A is offline
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Join Date: Oct 2007
Location: Stockholm, Sweden
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Neupogen and risk for AML transformation

Hi Chirley,
Yes, we really do get different treatment. You know when my dx was myelofibrosis I didn't get Neupogen though my neutrophils were 0.3 after 3 infections because the bone marrow is supposed to recover much better in myelofibrosis patients. Then I got neutropenic fever and a new BMB showed MDS.

I had probably had this disease from dx because I don't have spleen enlargement or symptoms like fever, night sweats, weight loss and fatigue. Since then I have got Neupogen mostly 2 injections/week. I avoid everything that eventually could give an infection and havn't been infected since the summer 2007 (knock on wood).

In Sweden the doctors don't think that Neupogen or similar drugs increase the risk for leukemic transformation. They have done several long term follow up studies. You could look at page 55 of this dissertation from 2008.
http://diss.kib.ki.se/2008/978-91-7409-100-7/thesis.pdf

Too bad with the cut in your hand and cellulitis .
Kind regards
Birgitta-A
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