[Chirley]

Hi Susan L,

I was on Vidaza for 3 cycles and my MDS progressed from RCMD to RAEB in that time.

I also developed an ataxia with sensory loss in both legs to the mid thigh. This is not a known side effect of Vidaza but it seems to be slowly improving with the postponement of this last cycle of Vidaza. Coincidence??

Other than that I had extreme fatigue and increased blood transfusion requirements. My platelets which had always been normal also dropped but not to anything too dramatic.

I developed fever in the low 38s a few days into every cycle. This required IV antibiotics for 5 days each cycle just to be sure I hadn't developed an infection.

I had no nausea/constipation/diarrhoea etc., but then I was always given IV tropisatron (sp) prior to the Vidaza. I was on IV Vidaza 7days in 28.

We all seem to react differently to drugs and I wish you luck with Vidaza. It's been shown to be very effective for a lot of people on this forum and I had high hopes for it as well.

Keep well.

Chirley