Hi Vince,
Removal of the spleen (splenectomy) is uncommon in MDS, but for some it may be advantageous. Here is a link that you can review:
http://www.aamds.org/aplastic/diseas...is__disease_e/
You can find many other links by googling "splenectomy + MDS". I am going to have a splenectomy next month as my spleen is greatly enlarged and quite uncomfortable and sometimes painful. The procedure is not without risks, but usually benefits those with low platelet counts. In my case, I do have a low platelet count, but in addition I have been diagnosed with ITP (immune thrombocytic purpura) and myelofibrosis. The removal of the spleen is more common for the latter two conditions than MDS. You'll need to talk with your doctor to find out just why he/she thinks removal would be beneficial.
The spleen is part of the immune system and besides taking out non-functioning cells it also holds a type of white blood cell that fights infections. And here is where a distinct risk is encountered - without a spleen you're less able to fight infections. In preparation you'll be required to get additional vaccines to reduce your chances of getting certain infections.
You can learn much more about the removal of the spleen by googling "splenectomy".
Wishing you the best,
Gipper