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Hi Lisa,
I've noticed that my cyclosporine trough has creeped up along with my creatinine the longer that I am on the drug. I'm guessing it is because my kidneys aren't filtering the drug as well as in the past. Have you noticed this with Ken? Perhaps a lower dose today is the same as a higher dose taken previously because of the increased concentration in his system?? I've noticed that even a small decrease in dosage (25mg) can make a HUGE difference in side effects.
Also, has Ken had his cholesterol checked recently? I was shocked to see the increase in my LDL but have since read that it can happen as a side effect of cyclosporine. There also may be a link between high blood pressure and high cholesterol.
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58 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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