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Old Sat Mar 19, 2011, 04:57 PM
Neil Cuadra Neil Cuadra is offline
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Join Date: Jul 2006
Location: Los Angeles, California
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I usually refer to this table from 2008, which shows the most commonly affected chromosomes and whether they indicate a relative better or worse prognosis.

Chromosome 18 doesn't appear in the chart, so it must be a less common abnormality, as you've observed.

I spotted a 2006 report of a study of complex chromosomes in MDS and AML patients in which they found that 4 of 17 patients had abnormalities in chromosome 18, so it's not unheard of. However, they were studying only patients who also had chromosome 5 abnormalities, and chromosome 5 is much more predictive.

My wife had a similar situation, with uncommon abnormalities for which we couldn't find research results. Her doctor said that having no abnormalities is better than having any abnormality, that having an non-studied one is better than having one with a known negative prognosis, and having abnormalities that are stable is better than finding different abnormalities from one bone marrow biopsy to the next.
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