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Thalidomide-Prednisone
My husband was started on Thalomid (100mg) and Prednisone (30mg) per day 2-1/2 months ago. He has not had any changes except slight lowering of RBC, platelets still marginal (59) and increase in WBC (1.78-2.8). His RBC/HGB has been low normal since Dacogen with WBC and Platelets the biggest problems since the beginning. All lines used to be low. Lack of sleep, shortness of breath, hyper, balance, dizziness, and leg cramps every night were his worst side effects in the beginning until the last week. Now those are better, but he is now somewhat weak, tired, irritable and tremors every 4-5 hrs.
He sees the doctor tomorrow and he wasn't pleased with how things were going at that time. Now I wonder if starting to taper the Prednisone would help some of these symptoms. It seems most people who respond to this regimen do so after three mths. Is that right? Any ideas? Is it worth a longer trial since some of the side effects are better? He has still been miserable until the last two days.
This is probably too long, but it is confusing as usual with this disease. Thanks for your input and support.
Beth
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Husband -MDS RAEB; Dx 4-07;age 73; Blasts 6.6%. Dacogen successful for 2 yrs; WBC (1.21-2.3);Platelets-12; RBC 2.22. Lenolid 100 mg and Pred(30mg) 4m. Disc. Procrit & Neupogen 3wk for last 3m. Trx every 2 wks. Platelet trx 2wks past. Started Vidaza 3-12-12 five days on, 3 wks off.
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