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+8
Bergit,
I am also a sole +8 MDS. A lot of the research that has been done over the years has the nasty habit of including +8 with other cytogenetic abnormalities and then creating a prognosis on this basis. This is also done frequently with AML. A small handful of researches in the US have been hypothesizing recently that +8 cells don't necessarily mean poor prognosis. An example is that treatment with ATG on +8 patients expands the size of the +8 clone, but also seems to improve symptoms in many of them.
When measured alone, recent studies indicate that +8 has been confirmed as an intermediate status for both AML and MDS. When combined with other cytogenetic changes, there is a worse prognosis.
A couple of studies regarding Vidaza and the experimental drug Estybon have both shown favorable characteristics in Trisomy 8 patients, but these are both very small studies. Overall, there really isn't as much research done on +8 as there has been on monosomy 7 del 5q.
Cheers
Dan
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MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
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