[Greg H]

Hi Birgitta!

Thanks for that reference. I'll try to post a couple of the studies I've run across on HDACs and the others so they are on marrowforums for folks to find. LynnI's recent update on her success with valproic acid got me digging through the net for information on HDAC inhibitors, and I found a few Phase I studies with small, but not unreasonable results. So I was surprised to find few on-going trials in low-risk patients. But I am still looking.

I would think that finding response in 20-25% of all types of MDS patients, given the heterogeneity of the disease, would be a result worthy of follow-up to try to determine which patients are more likely to respond. (I noticed the trial Cheri is hoping to enter was looking for at least a 20% response rate.)

But research moves slowly, and is likely dependent on rounding up funding.

Thanks, and take care!

Greg