Hey Folks!
Janice M asked an interesting question over in another thread that I thought might warrant its own conversation.
She asked:
Quote:
Originally Posted by Janice M.
One quick question, how does AA progress into MDS?
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And I said:
Quote:
Since being diagnosed with MDS, I have focused on MDS and not paid nearly as much attention to AA, despite the fact that some of my best buds on marrowforums are AA folks.
Consequently, I don't know the answer to that question, though I would love to understand it better.
My impression is that, in the space that you occupy, with your hypocellular marrow, it can be a bit tricky to differentiate AA from MDS. So "progression" from one to the other may be, I'll bet, not so much a change in condition as a change in diagnosis.
I do think it's an important question, particularly for you. Because the therapies that seem like a good idea for MDS are not always a good idea for AA -- Campath as a frontline therapy being one example: nice results in younger folks with MDS; not so good results as a frontline therapy for AA (with a few exceptions).
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So, what do y'all think? How
does AA progress to MDS? Or is it a matter of updated (or uncertain) diagnosis?
Thanks!
Greg
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Greg, 59, dx MDS RCMD Int-1 03/10, 8+ & Dup1(q21q31). NIH Campath 11/2010. Non-responder. Tiny telomeres. TERT mutation. Danazol at NIH 12/11. TX independent 7/12. Pancreatitis 4/15. 15% blasts 4/16. DX RAEB-2. Beginning Vidaza to prep for MUD STC. Check out my blog at
www.greghankins.com