Hi Layla,
Some patients become immunologically refractory to platelets. There are different ways to overcome this but that is complicated as you can see in this report.
http://www.ishapd.org/1999/47.pdf
There are reports about trials with Nplate in MDS patients with good results but still no reports about Promacta. Several patients from this forum have had positive responses with Promacta or Nplate. You will find their reports if you use the search function in the meny.
Nplate can increase blast cells and both drugs can increase fibrosis but they have so positive effects that they will probably be approved for MDS sooner or later.
How is your mother's platelet count and how many platelet transfusions is she getting/day now?
Kind regards
Birgitta-A