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I've never heard of cyclosporine resistance. Cyclosporine dependency is not that unusual though.
I think consulting with another doctor in person for a second opinion would be wise. My doctor told me (as I was tapering) that 2mg/kg/day was the *minimum* therapeutic dosage for cyclosporine. Unless your husband weighs 60 kg or less, he is below this dosage while taking 120 mg/day.
Has your husband been sick recently, had surgery, or anything else that would challenge his immune system?
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58 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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