Dear AG5594,
How sad with your Grandmother's severe symptoms. You know this forum is not for patients with Myelofibrosis but for patients with Myelodysplastic syndromes. You could ask your question about Jakafi and treatment for low platelets at one of the support groups for Myeloproliferative diseases (Myelofibrosis belongs to them) for example MPD Support
http://listserv.icors.org/scripts/wa...?A0=MPDSUPPORT
Blood transfusions and platelet transfusions should have some effect even if they don't increase counts much.
Kind regards
Birgitta-A
72 yo dx MDS 2006, very severe bone marrow fibrosis, txs dependent from dx. 2010 treatment with Thalidomide + Prednisone with positive effect.