I believ ewhat you are discribing is platelet refractory. My husband was refractory no matter what type of platelet he was transfused. His count was 2000-6000. The good news is that some individuals do tolerate this with out bleeding.
Definitions:
A patient is refractory to platelet transfusions if the patient’s circulating platelet levels fail to increase by at least 10,000/microliter after transfusion of an appropriate dose of platelets. There are multiple causes of platelet refractoriness, both immune-mediated and non-immune-mediated.
Immune-mediated refractoriness is due to antibodies made by the patient that recognize an epitope on the transfused platelets, most commonly human leukocyte antigen (HLA) class I. Patients produce these antibodies as a result of prior sensitization to specific HLA proteins through prior transfusions, organ transplantation, bone marrow transplantation, or prior pregnancies.
Non-immune-mediated refractoriness is due to a process that significantly decreases the circulation time of transfused platelets. Non-immune causes include splenomegaly, diffuse intravascular coagulopathy (DIC), fever, infection (sepsis), ongoing bleeding, graft-versus host disease, veno-occlusive disease, and some medications.
My prayer to you and your family. Keep in mind no two patients with MDS are alike nor respond the same.
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Kris, wife of Rick. DX; MDS/ Ringed Siderblast 5/2006. Supportive care, then Vidaza x 25 mo. HSCT 11//1/11 doing GREAT!
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