Hi Rob,
As Dan wrote your wife probably has Myelofibrosis. I had that dx during one year and still belong to four support groups for MF patients. Here is a link to one of them:
http://listserv.acor.org/SCRIPTS/WA-ACOR.EXE?A0=MPN-NET
MF is rather different from MDS - you will get better info from members in MPN-NET about spleen problems, drugs and Stem Cell Transplantation.
Hypercellular marrow means too many cells in the bone marrow compared with healthy persons at the same age.
Blast cells are immature cells - in the bone marrow should they not be more than 5%. Increased blast cells indicate a more serious disease. Good that your wife doesn't have that.
Kind regards
Birgitta-A
73 yo. Preliminary dx 2006 MDS. After the first BMB the dx was changed to MF with very severe fibrosis. After neutropenic fever 2007 the dx was changed back to MDS. Supportive therapy with txs, drugs for iron overload and Neupogen for low white blood cells until 2010. Since then positive results with Thalidomide + Prednisone