300 wouldn't be that high depending on how low his red cell were at the time. But if it was 300 with a normal HGB level, then it's bordering on too high.
Hemochromatosis is not triggered by transfusions but it can present later in life.
Just to confirm, he's only had two units transfused in total right?
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K.
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