Quote:
Originally Posted by Lisa V
Since ATG is designed to target the T-lymphocytes, wouldn't you want them to be low following treatment? I realize there are other lymphocytes besides the T cells, but I'm not sure what the percentage is. Anyone know?
|
Here is a recent article from Blood that talks about this. It says:
"Horse ATG is considered moderately lymphocytotoxic through the action of polyclonal Abs that produce transient lymphodepletion (usually 1-2 weeks duration) and longer elimination of activated T cells, which are assumed to contribute to the induction of tolerance. Rabbit ATG is more efficient at depleting peripheral blood lymphocytes in vivo and is more cytotoxic on a weight basis in vitro."
http://bloodjournal.hematologylibrar...119/2/345.long
__________________
58 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
|