[tytd]

Hi Liz,
I hope that your husband is responding to the Vidaza. Testing for point mutations such as RUNX1 and ETV6 is on the cutting edge so you must be going to an uptodate center. An article published about 2 years ago in the New England Journal of Medicine described certain mutations that would seem to indicate a poorer prognosis in MDS. RUNX1 and ETV6 were 2 of these as I am sure that your husband's doctor has told you. That is probably why he has indicated that transplant might be the best route. Of course, the blast percentage and abnormal karyotype also puts him in the higher risk IPSS category. Whether he is in good health other than the MDS , that is, whether he has any other comorbidities or other illnesses will make a difference as to his ability to survive a transplant . How is he tolerating the Vidaza and may I ask what his blood counts at diagnosis were? Good luck to both of you. Tytd