[Greg H]

Hi Audrey!

There really no one size fits all answer to your question, but the point that DanL made is important. There have been a few different studies over the years that look at transplant timing for MDS, and the answer always seems to be that folks with low risk disease live longer if they delay transplant until their disease progresses while folks with high risk disease tend to live longer if they transplant sooner. Again, that's all based on fancy math and averages, like everything else you read about MDS.

It's my impression that Vidaza pretty much always quits working at some point. I'm not aware of anyone going years and years on Vidaza (but I'm ready to be enlightened on that score). So it may be a not a matter of "if" the Vidaza quits working, but rather "when" it quits working.

You might want to talk with your docs about that point. It could be, as others have suggested, that they want to transplant while it is still working because some studies have indicated that is a good strategy.

It's really great that your husband is in excellent health. Folks who have other health problems are more likely to have problems with transplant.

Take care!

Greg