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Hi, Cheryl--My husband is currently going in for testing every three months, and his lab results come back listing "large" or "giant" platelets about half the time, or maybe more like two-thirds. It comes up a lot. His platelets average about 130.
But hypo granular neutrophils has never come up that I can recall. Instead, he used to get "toxic granulation" back a lot, and more recently he has been getting that plus "vacuolated neutrophils" and "Dohle bodies." His WBC count has been around 1.9 to 2.0 and his ANC around 900.
My impression is that his hematologist views these results, including the large platelets, mostly as a sign of intense bone marrow stimulation. I think she said large platelets tend to be younger, which suggests that the bone marrow is releasing them somewhat prematurely in an effort to keep enough of them in circulation.
He's going back in this coming week but seeing a new person, so I'll ask him to inquire again.
Take care,
Barbara
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