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May have an answer to my own question
I may have found the answer to my own question. Dr. David Steensma, (physician at the Dana-Farber Cancer Institute and professor at Harvard Medical School) wrote the following in “Understanding Chromosome Analysis – Part 3: MDS-Related Chromosome Abnormalities And How They Affect Prognosis And Treatment Decisions.”
Only a small number of chromo¬some patterns are counted in the IPSS, including the five most common MDS-associated abnormal patterns: loss of part or all of chromo¬some 7 or loss of the entire Y chromo¬some, deletion of the long arm (q arm) of either chromo¬some 5 or chromo-some 20, and the presence of complex patterns in which there are three or more abnormalities in the same cell.
The complete article can be found here:
http://www.mdsbeacon.com/news/2013/1...decisions-mds/
My impression is that 46,XY,t(7;18)(q11.2;q12.2)[2]/46,XY[19] would not be considered abnormal with respect to the IPSS or IPSS-R. I would still be interested in anyone else’s thoughts on the subject.
Thanks
Data
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Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016.
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