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Hi prayingrbc,
My comments are assuming that your dad is taking the modified form of cyclosporine (like Neoral or Gengraf), not SandImmune.
200 mg twice a day seems like a safe therapeutic dosage for cyclosporine. That works out to roughly 4.5 mg/kg/day which is right in the recommended range.
I also started on too high a dosage and then went down to a saner dosage of 4 mg/kg/day. This worked for me, and ~7 months after ATG, I had a slow upward trend in my counts.
Research now suggest that too much cyclosporine does not make it work better but just adds toxicity.
So, based on my experience, 200 mg twice a day is a good dosage and should be better tolerated than his previous high dosage.
Wishing him well -
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58 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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