I havent' posted in a while, but I read through periodically. Hubby has treatement related MDS from years and years of treatment for lymphoma. He had a allo on 11/24/14 using his brothers stem cells. Did great at first, about 4 months after was back in hospital with severe gvhd in gut. About 3 months ago, chimerism kept going down, down, last one was 4% donor only. Bm biopsy shows trisomy 8 back and MDS no blasts however. Prepping to do DLI, but a few things happened, 1) insurance change, 2) salmonella poisoning 3) shingles outbreak 4) stomach flu. BM biopsy of 2 weeks ago showes 8% blasts. So his diagnosis changed a little to read: "Variably cellular marrow with erythroid preponderance and scattered multilineage dysplasia, consistent with myleodysplastic syndrome/refractory anemia with excess blasts (MDS/RAEB-1) - Immunostains confirm increased blasts - Flow cytometric studies demonstrate abnormal myeloblasts with aberrant expression of CD7 and CD56.
They said they need to do the DLI sooner rather than later (I was hoping to let my husband "heal" a little from all the crap thats been thrown at him. I believe they are worried about 1) his lymphoma coming back aggressive and 2) his MDS moving to AML - as it seems it's on some kind of path already - I don't know nearly enough about MDS - I immersed myself in learding all about lymphoma, but MDS has been a hard one for me to understand. They want to do his DLI but give him fludarabine and some sort of antibody (I can't remember the acronym for it but they said it was derived from horses).
Any insight and expereince in MDS transforming to AML - is it a slow process? fast?
