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DDX41 Hereditary MDS, AML
I recently found out I have a mutation of DDX41.
You can google lots of recent papers and research, but this is quite interesting and should be closely looked at if you have any family related blood cancers.
My Father had AML and past some 27 years ago. Now I have MDS for the last 8 years or so. Basically I had a 50/50 chance of inheriting from my parents and the same goes for my offspring. My sibling who is a bmt match now also has MDS. My other 2 siblings are not matches but are fine. I don't know if they have DDX41 mutation (yet). More to follow I'm sure.
https://consultqd.clevelandclinic.or...lder-patients/
http://www.mdpi.com/1422-0067/17/6/838/pdf
http://www.bloodjournal.org/content/...o-checked=true
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Male 56, MDS 2008, pre SCT Hypocellular 5-30%, Normal Cytogenetics. WBC 500, anc 45, Blasts 15%, Platelets 45, HGB 7, RBCC 1.71, HCT 20.5, MCV 120. Became Transfusion dependent 3/2016. 5 cycles VIdaza started 3/14/16 which reduced Blast counts. . Marrow Transplant 9/1/16, Hereditary MDS/AML.
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