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Dacogen cycles timing
My husband has had 2 cycles of dacogen, due to start third on Monday. He has had a rough time for 2 weeks after the treatment week. It made him have major acid reflux. He couldn't eat for almost 7 days. Started Prevacid, and after about a week it seemed to work. Then cycle 2 treatment and it was almost like he wasn't taking the prevacid. Needless to say he lost weight during these episodes. He also wound up in the hospital for a week, because his WBC and Neuts nearly bottomed out (WBC 0.8). He had Neutropeenic fever, and pneumonia. He has been home now for a week. Felling better.
My question is about the timing of Dacogen. I believe the protocol said 4 weeks off, but Bob has only had 3 weeks off in between treatments. Has any one had it this way?
He has had to have transfusions more too. He has had Whole blood 3 times, and Platelets 5 times. I think this means the Dacogen is working, I just hope he won't have to go through too many more cycles, before he is ready for BMT.
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Linda, Wife of Bob, dx REAB-1 19 Jan. 06. Beginning numbers 19% blasts, Vidaza for 10 cycles then stopped responding, as of Apr 07 REAB-T Blasts at 20 (AML). 2 cycles of Dacogen May and June, 3rd in Sep. Counts bottomed out (WBC and Plts). BMB in Oct. showed blasts at 51%. NC
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