When I asked if he had mutations, the Doctor said no. When I say "He is being treated as RAEB 1, I am saying this because of information I have gotten here from you
His final diagnosis states:
Blood, Dry tap marrow aspirate, and bone marrow biopsy showing:
1. Hypercellular marrow with panyelosis (cellularity 80%)
2. Megakaryocyte atypia
3. Focally increasted blasts (10%)
4. Moderate reticulin fibrosis (MF grade 2 out of 3)
5. Overal findings most suggestive of MDS RAEB 2 with myelofibrosis but clinical correlation is advised (see diagnosis comment)
Diagnosis comment:
Unfortunately, the lack of marrow aspirate for morphologic analysis limits the ability to assess for dysplasia and precise blast percentage, but given the increased marrow fibrosis, additional repeat marrow aspirate attempts are unlikely to be successful. A myelodysplastic / myeloproliferative overlap syndrome is also within the differential, particularly if the patient has splenomegaly. Cytogenetics results will be of interest but given the dry tap aspirates, results may not be obtainable. One potential justification for a repeat marrow biopsy would be to send a portion of the biopsy for karyotype. Regardless, it is strongly recommended to send a peripheral blood sample to the BCCA for JAK2 analysis.
**** I was told his JAK2 was negative, but now, after typing this out, I have just realized that there is no way they tested him for JAK2, because he never had a "repeat Bone Marrow Biopsy". I guess I have another question for the Specialist. /sigh (okay nevermind I read that wrong again. haha. Dangit)
Thank you so much Bailie!! I appreciate your comments and help so much!!