Hi Steve,
You know AMG 531/Romiplostim/Nplate is not OK for MDS patients - many patients in trials have had increased symptoms
.
"Hematological Malignancies and Progression of Malignancy in Patients with a Pre-existing Hematological Malignancy or Myelodysplastic Syndrome (MDS)
-- Nplate stimulation of the TPO receptor on the surface of hematopoietic cells may increase the risk for hematologic malignancies. In controlled clinical studies among patients with chronic ITP, the incidence of hematologic malignancy was low and similar between Nplate and placebo.
-- In a separate single-arm clinical study of 44 patients with myelodysplastic syndromes (MDS), 11 patients were reported as having possible disease progression, among whom 4 patients had confirmation of acute myelogenous leukemia (AML) during follow-up.
-- Nplate is not indicated for the treatment of thrombocytopenia due to MDS or any cause of thrombocytopenia other than chronic ITP."
http://www.reuters.com/article/press...008+BW20080822
Perhaps the next drug for low platelets Eltrombopag/Promacta/Revolade will have a positive effect
.
Kind regards
Birgitta-A