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Hi B-OK,
You probably still want to discuss this with her doctor.
In the abstract, on day 8 the patients decreased their Cyclosporine dosage 50%. So, that resulted in the great reduction in availability.
Although the worse probably occurred on day 4, your wife could still be getting higher than desired amounts of Cyclopsorine.
Unfortunately, my doctors weren't able to tell me what an alarming number for Cmax would be. I don't think as much research has been done on this as on the trough level. However, the trough isn't always telling, as this article indicates. Please let me know if your doctors have any insight on this.
How long does she need to take fluconazole?
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58 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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