Bone Marrow Report- Any interpretations?

[CatherineJ]

Hi all,

My last biopsy report was just edited and I do not really understand it. Any explanations would be greatly appreciated.

"The karyotype is normal.

Microarray CGH revealed a 255kb duplication at 6q27 (clonal fraction 85%) This finding was confirmed by FISH (93% of interphase cells). In the setting of a recovering aplastic anemia, this finding may represent an oligoclonal repopulation rather than being strongly suggestive of a primary clonal disorder such as an MDS.

No significant genomic imbalances (losses or gains) were identified for other regions including chromosome 5, 7, 8, 20 and Y. SNP array analysis showed NO significant uniparental disomy (UPD) across the entire genome.

In summary, the clinical significance of the duplication is unclear and, most importantly, there are no changes detected that would be typically associated with an MDS."

The report originally said that there was no overt dysplasia seen and 20-30% cellularity.

I don't know if this means that I am recovering from Aplastic Anemia or something in between AA and MDS, or some kind of marrow failure due to toxins.

Thank you!

Catherine

[CatherineJ]

I also was wondering if anyone had suggestions for getting a second opinion. I've had two completely different diagnoses now, so I want to seek another opinion for peace of mind. I live in Upstate New York, so I was thinking of a doctor somewhere in NYC or Boston.

Thanks again for help!

[billyb]

http://www.ghr.nlm.nih.gov/chromosomes

[billyb]

http://users.rcn.com/jkimball.ma.ult...romosomes.html

[billyb]

Just a couple links, if you havent allready seen them....Billy

[MelanieW]

Dear Catherine
I also live in upstate New York, and I receive treatment in Boston at Dana Farber Cancer Institute. Feel free to email me at mwelch39@gmail.com

[Garnsy]

Originally Posted by CatherineJ

I also was wondering if anyone had suggestions for getting a second opinion. I've had two completely different diagnoses now, so I want to seek another opinion for peace of mind. I live in Upstate New York, so I was thinking of a doctor somewhere in NYC or Boston.

Thanks again for help!

Catherine-

Have you looked into visiting the Mayo Clinic in Rochester, MN. Im 34 years old, and I was diagnosed with MDS in the spring of 2010, and had a successful allogenic transplant on August 4, 2010.

The doctors and nurses that I saw at Mayo were amazing and I personally wouldn't have gone anywhere else. I am alive and well 2 1/2 years post transplant! If you are looking for a second opinion, I would check out Mayo.

If there is anything else you need to know, I'd be more than happy to answer your questions.

Take Care,
Chris

[kris]

Originally Posted by CatherineJ

I also was wondering if anyone had suggestions for getting a second opinion. I've had two completely different diagnoses now, so I want to seek another opinion for peace of mind. I live in Upstate New York, so I was thinking of a doctor somewhere in NYC or Boston.

Thanks again for help!

Rochester new York has a very good program, I believe it is at Strong Memorial.
You can never get too much information and a good rapport is so important.
Prayers.